璐濇柉鐗瑰甯冩柊鍨婤CL2鎶戝埗鍓侻esutoclax鑱斿悎濂ュ竷鏇垮凹涓€绾挎不鐤桟LL/SLL鐨勬敞鍐屾€II鏈熶复搴婅瘯楠屽畬鎴愭偅鑰呭叆缁

涓浗鍖椾含锛2026骞2鏈26鏃 鈥 鐢熺墿鍖昏嵂楂樼鎶€鍏徃璐濇柉鐗癸紙涓婁氦鎵€浠ｇ爜锛688428锛涢娓仈浜ゆ墍浠ｇ爜锛09969锛変粖澶╁甯冿紝鍏徃鑷富鐮斿彂鐨勬柊鍨婤CL2鎶戝埗鍓俶esutoclax锛圛CP-248锛 鑱斿悎BTK鎶戝埗鍓傚ゥ甯冩浛灏间竴绾挎不鐤楁參鎬ф穻宸寸粏鑳炵櫧琛€鐥/灏忔穻宸寸粏鑳炴穻宸寸槫锛圕LL/SLL锛夌殑娉ㄥ唽鎬II鏈熶复搴婅瘯楠屽凡缁忓畬鎴愭偅鑰呭叆缁銆

Mesutoclax鏄竴娆炬柊鍨嬪彛鏈嶉珮閫夋嫨鎬CL2鎶戝埗鍓锛孊CL2鏄粏鑳炲噵浜￠€氳矾鐨勯噸瑕佽皟鎺ц泲鐧锛屽叾琛ㄨ揪寮傚父涓庡绉嶆伓鎬ц娑茶偪鐦ょ殑鍙戠敓鍙戝睍鐩稿叧銆侻esutoclax閫氳繃閫夋嫨鎬ф姂鍒禕CL2铔嬬櫧锛屾仮澶嶈偪鐦ょ粏鑳炲噵浜锛屼粠鑰屾姂鍒惰偪鐦ょ敓闀垮拰鎵╂暎銆侻esutoclax涓庡ゥ甯冩浛灏煎浐瀹氱枟绋嬭仈鍚堜娇鐢锛屽皢涓轰竴绾緾LL/SLL鎮ｈ€呮彁渚涙洿娣卞眰娆＄殑缂撹В锛屽苟閬垮厤浜х敓鑰愯嵂绐佸彉锛屼负涓€绾緾LL/SLL鎮ｈ€呭甫鏉ヤ复搴婃不鎰堝笇鏈涳紝鎴愪负涓€绉嶆綔鍔涘法澶х殑娌荤枟鏂规銆

2025骞12鏈锛宮esutoclax澶氶」鐮旂┒鍦ㄧ67灞婄編鍥借娑插浼氾紙ASH锛夊勾浼氫笂杩涜浜嗗叕甯銆侻esutoclax鍗曡嵂娌荤枟鎴栬仈鍚堝ゥ甯冩浛灏兼不鐤桟LL/SLL鏄剧ず鍑鸿壇濂界殑鐤楁晥鍜屽畨鍏ㄦ€銆傛棤璁哄湪鍒濇不CLL/SLL杩樻槸澶嶅彂/闅炬不鎬 CLL/SLL锛堝惈鏃㈠線BTK鎶戝埗鍓傛不鐤楀け璐ワ級鎮ｈ€呬腑锛125姣厠mesutoclax鍓傞噺缁勭殑ORR鍧囦负100%銆傝仈鍚堝ゥ甯冩浛灏兼不鐤36鍛ㄦ椂锛屽鍛ㄨ涓嶅彲妫€娴嬪井灏忔畫鐣欑梾鐏讹紙uMRD锛夌巼涓65%銆

闄や簡涓€绾挎不鐤桟LL/SLL锛宮esutoclax姝ｅ姞閫熸帹杩涙不鐤桞TK鎶戝埗鍓傝€愯嵂鍚庣殑濂楃粏鑳炴穻宸寸槫鐨勬敞鍐屼复搴婅瘯楠岋紝骞惰幏寰椾腑鍥介涓獊鐮存€х枟娉曡瀹銆傛澶锛宮esutoclax娌荤枟鎬ユ€ч珦绯荤櫧琛€銆偹婱L锛夊拰楠ㄩ珦澧炵敓寮傚父缁煎悎鐥囷紙MDS锛夌殑涓村簥鐮旂┒姝ｅ湪涓浗鍜屽叏鐞冩帹杩銆

璐濇柉鐗硅仈鍚堝垱濮嬩汉銆佽懀浜嬮暱鍏糃EO宕旈渷鏉惧崥澹锛氣€淢esutoclax鏄叕鍙稿湪琛€娑茬槫棰嗗煙鍏锋湁鍏ㄧ悆绔炰簤鍔涚殑閲嶈璧勪骇锛岃礉鏂壒姝ｅ叏鍔涙帹杩沵esutoclax鍦ㄤ腑鍥藉拰鍏ㄧ悆寮€灞曠殑澶氶」涓村簥璇曢獙銆傝礉鏂壒鐨勮娑茬槫绠＄嚎涔熻兘鍙戞尌宸ㄥぇ鐨勫崗鍚屾晥搴旓紝灏ゅ叾鏄疊TK鍜孊CL2鎶戝埗鍓傜殑鑱旂敤鏈夋湜涓鸿娑茬槫鎮ｈ€呭甫鏉ユ洿澶ц幏鐩銆傗€

CLL/SLL鏄渶甯歌鐨勭櫧琛€鐥呯被鍨嬩箣涓€锛屾槸B娣嬪反缁嗚優鐨勪竴绉嶆儼鎬ф伓鎬ц偪鐦銆傚叏鐞冩瘡骞存湁19.1涓囨柊纭瘖鐨凜LL鐥呬緥鍜6.1涓囨浜＄梾渚^[1]锛屼腑鍥紺LL/SLL鐨勫彂鐥呯巼鍛堜笂鍗囪秼鍔^[2]銆  

鍏充簬璐濇柉鐗

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鍓嶇灮鎬у０鏄

鏈柊闂荤鍚湁涓€浜涘墠鐬绘€у０鏄庣殑鎶湶銆傞櫎瀵逛簨瀹炵殑闄堣堪浠ュ锛屾墍鏈夊叾浠栧０鏄庡彲琚湅浣滄槸鍓嶇灮鎬у０鏄锛屽嵆鍏充簬璐濇柉鐗规垨鑰呰礉鏂壒鐨勭鐞嗛儴闂ㄦ墦绠銆佹湡鏈銆佽鍒銆佺浉淇℃垨鑰呴鏈熷皢浼氭垨鑰呭彲鑳戒細鍦ㄦ湭鏉ュ彂鐢熺殑琛屼负銆佷簨浠舵垨鑰呭彂灞曟墍鍋氬嚭鐨勫０鏄銆傛绫诲０鏄庢槸璐濇柉鐗圭殑绠＄悊閮ㄩ棬鏍规嵁鍏剁粡楠屽拰瀵瑰巻鍙茶秼鍔裤€佸綋鍓嶆潯浠銆侀鏈熸湭鏉ュ彂灞曞拰鍏朵粬鐩稿叧鍥犵礌鐨勮鐭锛屽仛鍑虹殑鍋囪涓庝及璁銆傝鍓嶇灮鎬у０鏄庡苟涓嶈兘淇濊瘉鏈潵鐨勪笟缁锛屽疄闄呯殑缁撴灉锛屽彂灞曞拰涓氬姟鍐崇瓥鍙兘涓庤鍓嶇灮鎬у０鏄庣殑璁炬兂涓嶇銆傝礉鏂壒鐨勫墠鐬绘€у０鏄庡悓鏍峰彈鍒板ぇ閲忕殑椋庨櫓鍜屼笉纭畾鎬у洜绱犵殑鍒剁害锛岃繖鍙兘浼氬奖鍝嶈礉鏂壒鐨勮繎鏈熶互鍙婇暱鏈熺殑涓氱哗琛ㄧ幇銆

[1] 缇庡浗琛€娑插鏉傚織锛圓merican Journal of Hematology锛

[2] 鍖讳即鏃